The second Joint Action of the EU on Networks of Expertise on Cancer (JANE-2) was launched in Milan, Italy, on January 28-29, 2025. JANE-2 will be coordinated by Italy through the Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy, with 121 partners from 29 European countries. It is co-funded by the European Union (EU) with more than 40 million EUR dedicated to the project.